The most popular cars are also sometimes the most reliable. With a little searching, you can find many older Ford F-150s for sale with 300,000 miles or more used, and Consumer Reports has named the best-selling vehicle in America a strong candidate to go several hundred thousand miles. We wonder whether (or how) that will change once F-150 goes hybrid. It could very well become the Prius of pickups: economical and impossible to kill.